Don has got kids with four women:

 # 1: Twins with Cassandra Goth

# 2: a son with Nina Caliente

# 3 : At the same time, a daughter with Cassandra Goth ( I need to age her up )

# 4 : He got married and has a daughter with his wife.

# 5 : He cheated on his wife and Isis was pregnant with his twins ( I need to age them up too ).

# 6:  A son with his wife.